Pathology and Immunology

Trypanosomiasis and the nervous system: Pathology and immunology : Damage to the nervous system appear in both African and American trypanosomiases , but it differs appreciable  in form and extent in each disease, and with particular strains and disease stages. With Trypanosoma brucei infections there is a progressive central nervous system (CNS) pathology which associate the meninges, choroid, blood-brain barrier, and immune pathological changes including perivascular infiltrations, astrocyte activation and alterations in the cytokine/mediator network. These innovation underly the altered behaviour in the late or secondary disease stages, prevalent in the chronic gambian form, indicate by hypersomnia leading, if untreated or if treatment is followed by reactive changes, to coma and death.

 


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